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In avascular tissue zones, HIF-1 is stabilised (it is normally rapidly degraded under normoxic conditions by prolyl hydroxylase enzymes) and drives the transcription of dozens of hypoxia-response genes, including VEGF, erythropoietin, glucose transporters, and several matrix metalloproteinases involved in remodelling
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What are the main benefits of Vitamin B12 injections
After the sequencing of the human genome, in the early 2000s, the Broad Institute launched in 2010 the Connectivity Map, where numerous compounds were analyzed to find out what was their influence on the expression of genes
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